Lwona amaqiniso amane amahle awukubonakaliswa kokuqonda okujulile kweqiniso uBuddha ayenakho ngesikhathi sokuvuka kwakhe. Ngemva nje kwalokho wabe esehlanganyela lo mbono eParc des Gazelles eSarnath ngesikhathi semfundiso yokuqala ebizwa ngokuthi "The setting in motion of the Wheel of Dharma". Lawa maqiniso amane amahle akha umnyombo wemfundiso kaBuddha.
Iqiniso lokuqala elihle liwukubona okulula: lokho kokuhlupheka (dukkha). Ngempela, uma sibheka ngobuqotho ukuba khona kwethu, ngeke sikuphike ukuhlupheka ekuqukethe: kusukela ekuqaleni, ekuzalweni, kukhona ukuhlupheka kumama kanye nomntwana. Ezinye izigaba ezinjengokuguga nokufa nazo zihilela ukuhlupheka okukhulu. Ngokwesiko, uBuddha ubala izinhlobo eziyisikhombisa zokuhlupheka. Ngaphandle kokuzalwa, ukuguga nokufa, kusikhumbuza ukuthi ukugula kuwukuhlupheka, ukuthi ukungabi nalokhu esikufunayo kuwukuhlupheka, ukuthi ukuhlukaniswa nento esiyithandayo kuwukuhlupheka, kufana nokuhlotshaniswa nesingakuthandi.
Itemu lesiSanskrit elithi dukkha alimeli nje kuphela ukuhlupheka ngomqondo ongokwenyama kodwa futhi nakho konke ukunganeliseki esikuzwa njengabantu. Futhi i-dukkha inencazelo ebanzi kakhulu ehlanganisa zonke izinhlobo zokunganeliseki nokukhungatheka okuhlobene nokungapheleli, ukungapheleli, ukungazwani, nokungabi nalutho. Uma sikhuluma ngeqiniso elihle le-dukkha, ngakho-ke sikhuluma ngokuhlupheka kwabantu kuzo zonke izici zayo.