Lleptin is a peptide hormone that regulates fat stores in the body and appetite by controlling the feeling of satiety. This hormone is secreted by the white adipose tissue which, in addition to its function of storing and mobilizing fatty acids, also has a very important endocrine activity. Leptin is a peptide-like hormone, made up of 167 amino acids and discovered in obese mice.
Synthesized by adipocytes rather than by an endocrine gland, leptin is not strictly speaking a hormone, but its hormonal action allows it to be classified as such. This hormone regulates satiety and metabolism, by attaching to a receptor located on the hypothalamus.The level of leptin in the blood is directly proportional to the body's fat level. When we are resistant to the effects of this hormone then we get fat. Leptin resistance manifests itself much like insulin resistance, a precursor to type II diabetes. Thus, type II diabetes is the result of a very poor diet high in sugar and fat. The cells are constantly bombarded with insulin to get sugar into the cell (muscle and liver) which they eventually become resistant to insulin. The same goes for leptin. Since there is a high level of fat in the person in question, the leptin concentrations are very high. The cells are therefore bombarded with leptin which will eventually create resistance to this hormone.
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